Blood Clotting: Mechanisms and Stages

In this article we will discuss about the blood clotting and their Mechanism

• When an injury or trauma is caused, the wound does not continue to bleed for a long time.
• The blood stops flowing after sometime due to blood coagulation or blood clotting.
• This is a mechanism to prevent excessive loss of blood from the body.
• Inside an intact blood vessel, blood does not coagulate due to the presence of active anticoagulants, heparin and antithrombins.
• Procoagulants also occur in the blood but are in an inactive state.
• As soon as a blood vessel is ruptured, the injured area invites formation of a clot.

Mechanism of blood clotting

• Enzyme cascade theory proposed by Macfarlane & Co-workers.
• According to this theory there are 3 steps in blood clotting.

1. Releasing of thromboplastin

• Injured tissue and platelets synthesize thromboplastin
• These thromboplastin react with plasma proteins in the presence of Ca++ ions to form Prothrombinase enzymes.
• This enzyme inactivate heparin. (Anti-heparin)

2. Conversion of prothrombin into thrombin

• Prothrombinase enzyme convert inactive prothrombin into active thrombin in the presence of ca++ ion.

3. Conversion of fibrinogen into fibrin

• Thrombin acts as enzyme and convert fibrinogen (a soluble plasma protein) into long insoluble fibre like polymers called fibrin.
• Network of fibrin on cut or wound in which blood corpuscles got trapped. This form clotting of blood.
• After clotting a pale yellow liquid oozes from clot called serum.

READ MORE:

• Human Blood – Definition, Composition, & Functions
• Blood Group: Definition, ABO and Rh Blood Group System