Enzyme Inhibitors and Types Short Notes

Enzyme Inhibitors and Types Short Notes

In this article we will discuss about Enzyme Inhibitors and types:- What is enzyme inhibitors? Competitive inhibitors, Noncompetitive inhibitors and allosteric inhibitors

What is enzyme inhibitors?

  • Enzyme Inhibitors reduce the rate of an enzyme on the substrate
  • This effect may be permanent or temporary
  • Types of Enzyme Inhibition
    1. Competitive Inhibition
    2. Noncompetitive Inhibition
    3. Allosteric Inhibition

I) Competitive Inhibition

  • Inhibitor bind to active site of enzyme and block binding of the substrate
  • Inhibitors have a similar shape to the substrate molecule
  • Competitive Inhibition is usually temporary
  • Level of inhibition depends on the relative concentrations of substrate

II) Noncompetitive Inhibition

  • Inhibitor doesn’t block the substrate from binding to the active site
  • Inhibitor binding to a site other than the active site
  • Binding of the inhibitor causes a conformational change to the enzyme’s active site
  • As a result of this change, the active site and substrate no longer share specificity, meaning the substrate cannot bind
  • As the inhibitor is not in direct competition with the substrate, increasing substrate levels cannot mitigate the inhibitor’s effect

Enzyme Inhibitors and Types

III) Allosteric Inhibition

  • Alosteric means other site
  • These enzymes have two receptor sites
  • One site fits the substrate like other enzymes
  • The other site fits an inhibitor
  • Accumulation of the final product of the reaction is capable of inhibiting the step of reaction

More Important Topics

6 Factor Affecting Enzyme Activity Short Notes


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